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Can cell adhesion molecules help in determining the grade of astrocytomas?

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dc.contributor.advisor Sur ML en
dc.contributor.author Mitchell B en
dc.date.accessioned 2016-09-22T11:19:58Z
dc.date.available 2016-09-22T11:19:58Z
dc.date.created 1998 en
dc.date.submitted 2003 en
dc.identifier.uri http://hdl.handle.net/20.500.11892/111920
dc.description.abstract The research seeks to examine whether immunohistochemical evidence for expression of cell adhesion molecules, specifically E-cadherin, N-cadherin, gamma-catenin, epidermal growth factor receptor and CD44, correlates with the grade of astrocytoma, determined using standard histological procedures. Such a correlate would establish immunohistochemical techniques as a useful aid to diagnosis, especially when dealing with small fragmented biopsies. The grade of an astrocytoma is a crucial factor in predicting the behaviour of the tumour and thus patient prognosis. Nineteen cases of astrocytomas (four grade 1 pilocytic astrocytomas, seven grade 2 diffuse astrocytomas, six grade 3 anaplastic astrocytomas and two grade 4 glioblastomas) were collected from the archives of the Department of Anatomical Pathology; they constituted all the cases of astrocytoma which accumulated from 1998 to 2001. These were stained with E-cadherin, γ-catenin, N-cadherin, EGFR and CD44. The staining was assessed to be positive or negative and focal or diffuse. If positive, the intensity of positive staining was noted. Stains for E-cadherin and γ-catenin were negative in all the astrocytomas. N-cadherin stained low-grade astrocytomas focally and high-grade astrocytomas diffusely; it stained diffusely positive preferentially in anaplastic astrocytomas. High grade tumours stained diffusely positive with two or more of N-cadherin, EGFR and CD44 whilst low-grade tumours did not. Pilocytic astrocytomas were focally and intensely stained for N-cadherin but negative for EGFR and CD44. There was a strong correlation between EGFR staining and CD44 staining. Thus cell adhesion molecules may indeed be helpful in the grading of astrocytomas. en
dc.language English en
dc.subject Medical sciences: Anatomy en
dc.subject Anatomic embryology, cytology, histology en
dc.title Can cell adhesion molecules help in determining the grade of astrocytomas? en
dc.type Masters degree en
dc.description.degree M Med (Anatomical Path) en

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